I have had the good fortune to work on a wide selection of global clients.
My involvement is usually full end-to-end creation. The first step being early dialogue with project managers to plan our approach, then concepting and UX wireframes, design mock-ups, fully resposive builds, localisation to other languages, tracking implementation, Quality Checks, and finally, go live.
Working with high profile clients means watertight coding practices and short timescales. I have always strived for consistency and efficiency in my coding, which is why I would champion a robust framework and re-useable modules over a wholley bespoke 'ground up' solution. That final percentage of hand coding, however, will always sit harmoniously with the existing framework.